毛琦淇;沈广辉;吴芋芋;张谢;王帆;李慧;陈莉;刘彦隆;

• 1:宁波市医疗中心李惠利医院
• 2:温州医科大学精神医学学院
• 3:新疆医科大学第二附属医院
• 4:北京回龙观医院

摘要(Abstract)：

目的:探讨酒精依赖患者与正常群体在攻击性行为上的差异，及脑源性神经营养因子(BDNF)基因rs1519480多态性的调节作用。方法:选取421例符合精神障碍诊断及统计手册第4版(DSM-IV)酒精依赖诊断标准的成年男性与212例正常成年男性，采用Buss-Perry攻击问卷(BPAQ)中文版评估攻击行为，用TaqMan q-PCR(聚合酶链式反应)测定BDNF rs15194800基因多态性，采用倾向评分匹配(PSM)技术对混杂变量进行控制。结果:酒精依赖患者BPAQ得分高于对照组(P<0.01);酒精依赖与rs1519480多态性具有交互作用(两因素方差分析P<0.01)。酒精依赖患者BDNFrs1519480 TT等位基因携带个体BPAQ得分高于C等位基因携带个体(P<0.05);BDNF rs1519480 TT等位基因携带者中，酒精依赖个体BPAQ得分高于非酒精依赖个体(P<0.001)。结论:酒精依赖与BDNFrs 1519480基因可能共同调控攻击性行为，BDNFrs 1519480 TT等位基因高表达可能是酒依赖患者攻击性的危险因素。

关键词(KeyWords)： 酒精依赖;攻击行为;BDNF基因rs1519480;TT基因型

Abstract:

Keywords:

基金项目(Foundation):

作者(Authors): 毛琦淇;沈广辉;吴芋芋;张谢;王帆;李慧;陈莉;刘彦隆;

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