袁艺琳;伍庭芳;杜春雨;周天航;王婧;谭友果;文丽萍;朱灵艳;邱美红;潘杨;张长春;管丽丽;马弘;于欣;

• 1:北京大学第六医院北京大学精神卫生研究所国家卫生健康委员会精神卫生学重点实验室(北京大学)国家精神心理疾病临床医学研究中心(北京大学第六医院)
• 2:首都医科大学附属北京安定医院
• 3:北京市海淀区心理康复医院
• 4:自贡市第五人民医院

摘要(Abstract)：

目的:研究精神分裂症遗传高危人群失匹配负波及时频特征，探索精神分裂症遗传风险识别的客观指标。方法:采用横断面设计，纳入精神分裂症患者(SCZ)、精神分裂症遗传高危人群(FHR)及健康对照(HC)各19例。采用精神病风险综合征结构式访谈(SIPS)、阳性和阴性症状量表(PANSS)及阴性症状评估量表-16(NSA-16)评估精神症状严重程度，采用精神分裂症认知功能简短评估(BACS)评估神经认知功能。利用Oddball范式采集脑电信号，比较持续时间失匹配负波(dMMN)振幅，theta诱发功率及相位一致性(ITC)。结果:SCZ的NSA-16得分高于FHR及HC(P<0.001),BACS得分低于FHR及HC(P<0.001)。SCZ的dMMN振幅低于FHR及HC(P<0.05),theta诱发功率低于FHR及HC(P<0.05)。三组间ITC差异存在趋势(P=0.078)。结论:本研究未发现精神分裂症遗传高危人群与健康人群相比存在dMMN及theta振荡异常。

关键词(KeyWords)： 精神分裂症;内表型;失匹配负波;神经振荡

Abstract:

Keywords:

基金项目(Foundation): 北京市科技攻关计划(D171100007017002);; 北京市科技计划项目(Z191100006619113);; 国家自然科学基金(81401123)

作者(Authors): 袁艺琳;伍庭芳;杜春雨;周天航;王婧;谭友果;文丽萍;朱灵艳;邱美红;潘杨;张长春;管丽丽;马弘;于欣;

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