女性甲基苯丙胺戒断者工作记忆的可恢复性Restorability of working memory in female methamphetamine abstainers
刘兴嘉;桑墨涵;王一媚;上官士果;李爱文;颜景宇;赵宇飞;梁东波;韩磊;
摘要(Abstract):
目的:考察女性甲基苯丙胺戒断者工作记忆在戒断过程中的恢复情况。方法:从某戒毒所选取34名符合美国精神障碍诊断与统计手册第4版(DSM-IV)苯丙胺障碍诊断标准的女性,另外选取年龄和受教育年限相匹配的28名健康女性。对甲基苯丙胺依赖组和健康对照组进行3次纵向测评,每次间隔1个月,采用重复测量方差分析比较两组在不同测量时间下完成n-back任务的反应时和正确率。结果:甲基苯丙胺依赖组T_1的反应时长于T_2、T_3的反应时;健康对照组3次测量的反应时均小于甲基苯丙胺依赖组3次测量的反应时(均P<0.001)。甲基苯丙胺依赖组T_3的正确率高于T_1的正确率(P<0.01),健康对照组与甲基苯丙胺依赖组T_3的正确率差异无统计学意义(P>0.05)。结论:女性甲基苯丙胺戒断者的工作记忆随着戒断时间的增加逐渐恢复,但并未完全恢复到正常人的水平。
关键词(KeyWords): 冰毒戒断者;工作记忆;戒断时间;n-back任务
基金项目(Foundation): 国家自然科学基金——基于认知情感理论的在线教学优化设计“注意模式和认知神经机制研究”(62077034);; 山东省重点研发计划项目——戒毒人员戒毒效果的指标开发以及心理成瘾的机制和干预研究(2017GSF218076)
作者(Authors): 刘兴嘉;桑墨涵;王一媚;上官士果;李爱文;颜景宇;赵宇飞;梁东波;韩磊;
参考文献(References):
- [1] 中国禁毒网.2020年中国毒情形势报告[N].中国禁毒报,2021-7-16(3)
- [2] 杨文玲.个体化进程中青少年女性吸毒的行为过程研究[D].沈阳:沈阳师范大学,2020.
- [3] Ruan XL,Zhong N,Yang Z,et al.Gray matter volume showed dynamic alterations in methamphetamine users at 6 and 12months abstinence:a longitudinal voxel-based morphometry study[J].Prog Neuropsychopharmacol Biol Psychiatry,2018,81:350-355.doi:10.1016/j.pnpbp.2017.09.004.
- [4] Hwang J,Lyoo IK,Kim SJ,et al.Decreased cerebral blood flow of the right anterior cingulate cortex in long-term and short-term abstinent methamphetamine users[J].Drug Alcohol Depen,2006,82(2):177-181.
- [5] Alzahrani RA,Alzahrani,OM,Alherz,SH,et al.Isolated superior mesenteric artery dissection after methamphetamine use:a rare adverse effect[J].Cureus,2021,13(11):e19551.doi:10.7759/cureus.19551.
- [6] Thompson,PM.Structural abnormalities in the brains of human subjects who use methamphetamine[J].J Neurosci,2004,24(26):6028-6036.
- [7] Carlen M.What constitutes the prefrontal cortex?[J].Science,2017,358(6362):478.
- [8] Constantinidis C,Klingberg T.The neuroscience of working memory capacity and training[J].Nat Rev Neurosci,2016,17(7):438-449.
- [9] 李景业,郑志军,罗艳琳.慢性药物滥用对工作记忆的行为学影响[J].现代预防医学,2013(15):2835-2839.
- [10]Mielicki MK,Koppel RH,Valencia G,et al.Measuring working memory capacity with the letter-number sequencing task:advantages of visual administration[J].Appl Cognit Psychol,2018,32(6):805-814.
- [11]Maria JF,Miguel P,Antonio V.What are the specific vs.generalized effects of drugs of abuse on neuropsychological performance?[J].Neurosci Biobehav Rev,2011,35(3):377-406.
- [12]Van D,Crone EA,Van D,et al.Executive control deficits in substance-dependent individuals:a comparison of alcohol,cocaine,and methamphetamine and of men and women[J].J Clin Exp Neuropsychol,2009,31(6):706-719.
- [13]Falcone M,Wileyto EP,Ruparel K,et al.Age-related differences in working memory deficits during nicotine withdrawal[J].Addict Biol,2015,19(5):907-917.
- [14]Smith MJ,Cobia DJ,Wang L,et al.Cannabis-related working memory deficits and associated subcortical morphological differences in healthy individuals and schizophrenia subjects[J].Schizophr Bull,2014,40(2):287-299.
- [15]Chambers CD,Garavan H,Bellgrove MA.Insights into the neural basis of response inhibition from cognitive and clinical neuroscience[J].Neurosci Biobehav Rev,2009,33(5):631-646.
- [16]杨玲,张炀,张建勋,等.金钱奖赏对海洛因戒断者工作记忆刷新功能的促进作用减弱[J].心理科学,2021,44(2):391-397.
- [17]Mahoney JJ,Kalechstein AD,Verrico CD,et al.Preliminary findings of the effects of rivastigmine,an acetylcholinesterase inhibitor,on working memory in cocaine-dependent volunteers[J].ProgNeuropsychopharmacol Biol Psychiatry,2014,50:137-142.doi:10.1016/j.pnpbp.2013.11.001.
- [18]Zhao X,Wang L,Maes JHR.Training and transfer effects of working memory training in male abstinent long-term heroin users[J].Addict Behav Rep,2020,12:100310.doi:10.1016/j.abrep.2020.100130.
- [19]杨玲,张炀,曹华,等.海洛因依赖短期戒断者工作记忆的可恢复性[J].中国临床心理学杂志 2019,27(4):652-656.
- [20]李馨,李强,陈佳杰,等.强制戒断时间对海洛因成瘾者大脑局部一致性影响的静息态功能MRI[J].中国医学影像技术,2017,33(8):1171-1175.
- [21]Faul F,Erdfelder E,Lang AG,et al.G*power 3:a flexible statistical power analysis program for the social,behavioral,and biomedical sciences[J].Behav Res Methods,2007,39(2):175-191.
- [22]American Psychiatric Association.Diagnostic and Statistical Manual of Mental Disorders (DSM-IV)[M].Washington DC:American Psychiatric Association,1994.
- [23]陈小莹,马靓,孙本良,等.冰毒成瘾对工作记忆的影响[J].中国临床心理学杂志,2018,26(3):11-15.
- [24]Iudicello JE,Woods SP,Vigil O,et al.Longer term improvement in neurocognitive functioning and affective distress among methamphetamine users who achieve stable abstinence[J].J Clin Exp Neuropsychol,2010,32(7):704-718.
- [25]Nie L,Ghahremani DG,Mandelkern MA,et al.The relationship between duration of abstinence and gray-matter brain structure in chronic methamphetamine users[J].Am J Drug Alcohol Abuse,2021,47(1):65-73.
- [26]Zhang ZX,He L,Huang S,et al.Alteration of brain structure with long-term abstinence of methamphetamine by voxel-based morphometry[J].Front Psychiatry,2018,9:722.doi:10.3389/fpsyt.2018.00722.