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目的:探究男性甲基苯丙胺(MA)依赖者的奖赏功能的行为表现及前额叶激活特征。方法:招募15名男性MA依赖者和15名男性健康对照者，通过货币奖励延迟(MID)任务，并结合功能性近红外光谱技术测量奖励、中性和惩罚刺激条件下的行为学指标(正确率、反应时)和前额叶皮层激活水平，同时完成行为抑制/激活系统量表和Barratt冲动量表(BIS-11)。结果:MA依赖者在MID任务奖励、中性及惩罚刺激条件下的正确率均小于健康对照者(均P<0.01);奖励刺激条件下，MA依赖者的反应时大于健康对照者(P<0.05);中性刺激条件下，MA依赖者的左背外侧前额叶皮层激活水平大于健康对照者(P<0.05);MA依赖者的BIS-11总分大于健康对照者(P<0.05)。控制年龄和受教育程度后，两组在正确率、反应时、前额叶激活水平及BIS-11总分的组别主效应均无统计学意义(均P>0.05)。结论:男性MA依赖者的奖赏功能与健康成年人有异，表现为行为效率低下和更多认知资源消耗，但这种差异可能受个体差异性影响。
Abstract：Objective:To investigate reward function and its neural mechanisms in male methamphetamine(MA) dependents.Methods:Fifteen male MA dependents and fifteen male healthy controls completed the Monetary Incentive Delay(MID) task while functional near-infrared spectroscopy(fNIRS) measured behavioral indicators(accuracy rate, reaction time) and prefrontal cortex activation levels under reward, neutral, and punishment stimulus conditions.Participants also completed the Behavioral Inhibition System/Behavioral Activation System scale and Barratt Impulsiveness Scale(BIS-11).Results:In the MID task, MA dependents showed lower accuracy rates than healthy controls under reward, neutral, and punishment stimulus conditions(Ps<0.01).Under the reward stimulus condition, their reaction time was longer than that of healthy controls(P<0.05).Under the neutral stimulus condition, the left dorsolateral prefrontal cortex(DLPFC) activation level of MA dependents was higher than that of healthy controls(P<0.05).MA dependents had higher BIS-11 total scores than healthy controls(P<0.05).After controlling for age and education level, group differences in accuracy, reaction time, prefrontal activation, and BIS-11 scores were no longer significant(Ps>0.05).Conclusion:The reward function in male MA dependents differs from that of healthy adults, manifesting as reduced behavioral efficiency and increased cognitive resource consumption, although these differences may be influenced by individual demographic factors.
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基本信息:
中图分类号:R749.64
引用信息:
[1]李沙,邓晓琴,胥国华,等.男性甲基苯丙胺依赖者奖赏功能的行为表现及前额叶激活特征[J].中国心理卫生杂志,2026,40(04):342-348.
基金信息:
国家社会科学基金一般项目(24BGL254)
2026-03-05
2026-03-05
2026-03-05